Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Naive and memory T cells show distinct pathways of lymphocyte recirculation. MHC class I, MHC class II and intercellular adhesion molecule-1 (ICAM-1) expression in inflammatory myopathies. Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines. Immune surveillance against a solid tumor fails because of immunological ignorance. Can B cells turn on virgin T cells? Nature 334, 253–255 ( 1988). Rapid evolution of encephalomyocarditis virus infection. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum.
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Gresser, I., Tovey, M.G., Bandu, M.E., Maury, C. Type I IFNs enhance the terminal differentiation of dendritic cells. IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2. The cell surface phenotype of human interferon-alpha producing cells as determined by flow cytometry. Swensson, H., Johannisson, A., Nikkila, T., Alm, G.V. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Indirect T cell recognition in allograft rejection. The biochemistry and cell biology of antigen processing and presentation. Constitutive class I-restricted exogenous presentation of self antigens in vivo. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha(v)beta3 integrin and requires intracellular and extracellular calcium. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. Immunosuppressive effects of apoptotic cells. Evidence for a mechanically induced oxidative burst. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.
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Generation of large numbers of dendritic cells from mouse bone marrow culture supplemented with granulocyte/macrophage colony-stimulating factor.
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Efficient presentation of soluble antigen by cultured human dendritic is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
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Tolerance, danger, and the extended family. Activated platelets induce tissue factor expression on human umbelical vein endothelial cells by ligation of CD40. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
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Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. Innate immunity: the virtues of a nonclonal system of recognition. Approaching the asymptote? Evolution and revolution in immunology. Developmental regulation of MHC class II transport in mouse dendritic cells. Dendritic cells and the control of immunity. Origin, maturation and antigen presenting function of dendritic cells. The dendritic cell system and its role in immunogenicity.